The objective of this work was to investigate the effect of compression force on release rate characteristics of paracetamol tablets which were prepared by wet granulation method using PVP-K30 as binding agent. Compression properties of the formulations were assessed by compression equation of Heckles. The mechanical properties of the formulations were evaluated using crushing strength and friability, weight variation test, drug content, hardness, friability, disintegration and in vitro release studies. The drug release properties of the tablets formed were assessed using disintegration and dissolution times. The in vitro dissolution study was carried out for one hour using United States Pharmacopoeia USP 2 (paddle-type dissolution apparatus) in phosphate buffer (pH 6.8) as dissolution media. All the tablet formulations showed acceptable pharmacotechnical properties and complied with pharmacopoeial specifications. The release mechanisms were explored and explained with first order equation. The results indicated that Tablet formulations containing PVP-K30 as binder with compression force of 3kg/cm2 showed greater percentage drug release compared to 4.5 kg/cm2 and 7 kg/cm2.
Loading....